Life science research needs to be strengthened

On the other hand, the field of experimental animals involves zoology, medicine, pharmacy, statistics and other fields, "the number of colleges and universities offering experimental zoology is small, the personnel training system is not perfect, and the professional and technical personnel are lacking." Finally, the construction and operation of the experimental animal platform requires huge investment, the direct economic benefits brought by the investment are not significant enough, and the return on investment is low, which also affects the innovation and development of the animal experiment industry to a large extent.

The root of the problem: lack of people to do the basic work of the application

What are the reasons for these problems? Wang Xiaoning believes that in terms of high-end instruments and equipment, domestic equipment lacks incentive policies and international certification standards, and the credibility is low. Investment in major information facilities, experimental animal bases and key technological innovation bases is too low, or even vacant, and is not sustainable. In addition, capital investment is eager for quick success, rarely involved in original drugs, equipment, and serious follow the trend has also had a contributing impact.

"We don't have the people who are actually doing the basic application work." Wang Xiaoning said that in the research found that many rely on foreign technology, China's own talent, technology, concept are no problem, can develop independently, but there is no solid to do. "Equipment or instruments or consumables, these key technologies, let graduate students to do he will not do, tutors will not do, why?" Because doing this, the ranking of a university does not have a great weight on the application of academicians and results."

At the same time, Wang Xiaoning believes that the country's investment in life science infrastructure is still insufficient. However, the capital market has developed greatly in the past two years, but due to the lack of regulation and guidance, "always follow the trend, and rarely get involved in real innovative drugs." Wang Xiaoning said that the field of targeted drugs is a case of capital piling up to follow suit. "In the first half of 2020, we have 484 clinical trials, more than 50 waiting for the market, there is no one like this in the world, CAR-T has not been listed, there are 357 registrations, globally and concentrated in myeloma this niche disease, 26 in the United States, we have 24, whether these are necessary, is worth our in-depth consideration of the issue." "Wang Xiaoning said.

How to solve problems: Leading Big Science projects is the edge of solving problems

In Wang Xiaoning's view, the source research and industrial transformation of life sciences should become the top priority of the 14th Five-Year Plan period. "We must make life sciences and medical and health services the top priority of the country's development in the next stage, and we must conduct in-depth research and adjustments in terms of investment and orientation."

At the same time, he also stressed that it is necessary to strictly define the technology of "stuck neck" to avoid the generalization of the concept of "stuck neck", "what is" stuck neck "certainly not, must be the key technology, and this" stuck neck "can not be said just now, but also from the future development of the entire discipline to consider."

In order to avoid the generalization of the concept of "card neck" in the field of life sciences, according to Yu Jianrong, director of the Shanghai Life Science Information Center of the Chinese Academy of Sciences, at present, a key technology "white list" is being developed, and will be widely solicited in various areas of urgent need to solve the consumables, key reagents and other aspects of dynamic continuation, to provide decision support for the government, enterprises and industry.

For how to solve the problem of "stuck neck" in the field of life science, Yu Jianrong believes that there should be several steps to specific research and explore solutions: First, focus on the pain points of "stuck neck" in the field of life science, and explore a new path for the development of innovative models; Second, design a three-part strategic path from completely getting rid of dependence, going abroad, and realizing leading the world; Thirdly, it discusses the mechanism and policy suggestions for the establishment of new modes of technology integration development and academic industry development.

"If you want to change the current predicament of the so-called 'stuck neck', it is not to do it for a certain technology." Solve a technology, people change a technology, immediately change the track. So if you want to lead the world, you have to develop the original innovation." Wang Xiaoning said that in this regard, strengthening international cooperation and exchanges, leading the big science program is a sharp edge to solve the problem. "We know that big science projects, the first of which was to produce source innovations, such as the Genome Project, revolutionized the development of the entire life sciences. Second, the property rights of the big science project are shared at the source, so there is no one who owns the other." "Now that China has the strength and ability, we should encourage more efforts to undertake big science programs led by Chinese scientists, strengthen source innovation and resource sharing, and fundamentally break the 'bottleneck'," he suggested.