Development trend of life science and biotechnology in China

3. The basic research and mechanism analysis of stem cells have been deepened continuously, and they have taken the lead in some fields of organoids

China continues to deepen the field of basic stem cell research, breakthrough achievements are rapidly produced, and the research level has always ranked among the international leaders. At the same time, the pace of research in the field of organoids has been accelerating, and it has occupied the development opportunity in emerging directions such as organoid chips. In 2022, China has made a series of progress in the basic research of stem cells, including further optimization of haploid embryonic stem cell technology and chemical reprogramming technology, revealing a variety of new mechanisms for the maintenance and differentiation of different stem cells, and on this basis, realizing the differentiation of stem cells into a variety of cell types, especially the transformation of early embryonic-like cells. It also laid the foundation for the study of early human development.

At the same time, the transformation process of stem cell therapy in China is gradually accelerating. By 2022, the number of stem cell clinical trials filed in China has exceeded 100, and nearly 140 stem cell clinical research filing institutions have been approved. Through the Drug Evaluation Center (CDE) of the State Drug Administration, 21 new applications for clinical trials of stem cell-related drugs will also be accepted in 2022.

In addition, China has further made a number of breakthroughs in the clinical application of stem cell therapy research, opening up a new road for the treatment of a variety of diseases. The development speed of the field of organoids in China has been accelerating, and breakthroughs have been made in the construction of normal physiological and pathological organoids such as islets, spinal cord, and lung cancer in 2022, especially in the emerging direction of organoid chips, and China's research process has been in the forefront of the world.

This article is excerpted from the "2023 China Life Science and Biotechnology Development Report" (compiled by the Department of Social Development Science and Technology, Ministry of Science and Technology, China Biotechnology Development Center). Beijing: Science Press, 2023.10) The book "Chapter I General Introduction", with deletion and modification.

The "2023 China Life Science and Biotechnology Development Report" summarizes the basic situation of China's life science research, biotechnology and biological industry development in 2022. The research progress in the fields of bioomics and cell atlas, brain science and neuroscience, synthetic biology, epigenetics, structural biology, immunology, stem cells, emerging frontiers and cross-cutting technologies in China were highlighted. As well as the annual progress, major achievements and significance of medical biotechnology, industrial biotechnology, agricultural biotechnology, environmental biotechnology and biosafety.

This book makes a forward-looking analysis of the hot areas of China's biological industry, and analyzes the development trend of investment and financing from both international and domestic levels to reflect the financial support of science and technology plans in the field of biotechnology, the situation of venture capital and listing financing in the field of biotechnology, the hot direction of investment and financing, and the market performance and development trend of the biological industry.