In the field of pharmaceutical preparations, create a new blue ocean

Transdermal drug delivery techniques

Transdermal drug delivery (TDDS) or transdermal absorption (TTS) technology is the application of drugs on the skin, the drug components through the skin cuticle, into the dermis and subcutaneous fat to achieve the purpose of local treatment, or by the capillaries and lymphatic vessels absorbed into the human circulation, producing systemic therapeutic effects.

Solid dispersion technique

Solid dispersion system refers to the dispersion system in which the drug is uniformly dispersed in a solid carrier substance in the state of molecule, colloidal state and microcrystal.

Enhanced drug mucosal absorption technology

In the field of mucosal drug delivery technology, many researches at home and abroad include chemical absorption enhancers, biological adhesives, precursor drugs and enzyme inhibitors. Chemical absorption enhancers include various polymer materials, cholate salts, etc., which can improve drug permeability and prolong the mechanism of action of drugs on mucosal surface. Bioadhesives are mainly adsorbed to mucosal surface through the water absorption and swelling or surface wetting of drugs. Their advantages are reflected in that the drug action site can be the epidermal cell mucosa of various lumens, including the mouth, nasal cavity, eyes, etc., and the dosage form can be tablets, film agents, gels, etc. Since the mucosa has the structure of lipid bilayer, drugs with high lipid solubility are more easily absorbed through the mucosa. Researchers often design precursor drugs to promote drug penetration through the mucosa and improve the absorption rate. The principle of enzyme inhibitors is to add various enzyme inhibitors to the drug to prevent the enzyme distributed on the mucosal surface from degrading the drug, so as to promote the normal drug effect.

What are the domestic pharmaceutical companies of high-end preparations

Nanoparticle orientation

There are not many varieties for the registration and declaration of nano-preparations in China. The main products include fenofibrate tablets, progesterone nanocrystalline capsules, vinorelbine tartrate nanoparticle for injection, docetaxena rice granules for injection, amphotericin B complex phospholipid nanoliposomes for injection, alprostadil nanoparticles for injection, hydroxycamptocampin lipid nanoparticles for injection, irinoconor hydrochloride micelles for injection, paclitaxel nanoparticles for injection, etc.

The main distribution of enterprises are: National Nanoscience Center, Institute of Toxicology of the Academy of Military Sciences, Shanghai Medical Engineering Institute, Chongqing Lai Mei Pharmaceutical (more declarations), Jiangsu Hausen, Zhengda Tianqing, etc.

Liposomal orientation

For the registration and declaration of liposome preparations in China, there are relatively many varieties. The main products include oxaliplatin liposome injection, docetaxel (precursor) liposome injection, vinorelbine tartrate liposome injection, ribavirin liposome oral milk, amphotericin B liposome oral milk, vincristine sulfate liposome injection, Econazole nitrate liposome gel, doxorubicin hydrochloride liposome injection, epirubicin hydrochloride liposome injection, doxorubicin hydrochloride liposome injection Statin thermosensitive liposome injection, Irinotecan liposome injection, Indometacin liposome eye drops, Docetaxel liposome for injection, amphotericin B liposome for injection, Alprostil liposome for injection, hydroxycamptocampin liposome for injection, paclitaxel liposome for injection, etc.

The distribution of enterprises is mainly: Aikunwei Pharmaceutical, Changzhou Jinyuan Pharmaceutical (more declarations), Guangzhou Langsheng Pharmaceutical, Guangzhou Wanfangjian Pharmaceutical (more declarations), Jiangsu Aosaikang Pharmaceutical, Jiangsu Hengrui, Nanjing Luye Pharmaceutical, Nanjing Sike Pharmaceutical, Shanghai Fudan Zhangjiang Biological (more declarations), Kangping Pharmaceutical Research Institute of Shi Pharmaceutical Group, Shi Pharmaceutical Euitech Pharmaceutical (more declarations), Shi Pharmaceutical Zhongqi Pharmaceutical (more declarations), Xi 'an Libang Pharmaceutical, Zhejiang Haizheng, China Pharmaceutical University, etc.

Microsphere orientation

In China, for the registration and declaration of microsphere preparations, there are not many varieties on the whole, but the number of single-variety declaration and acceptance number is more. The main varieties are exenatide microsphere injection, vinorelbine tartrate lipid microsphere injection, perfluoropropanoin human blood albumin microsphere injection, octreotide acetate microsphere for injection, leuprelin acetate microsphere for injection, triprerelin acetate microsphere for injection, risperidone microsphere for injection, Rotigotine sustained-release microsphere for injection, etc.

The company distribution is mainly: Astrazeneca (China), Beijing Boant Pharmaceutical, Beijing Novartis, Shanghai Medical Engineering Institute, Institute of Toxicology of the Military Academy, Qilu Pharmaceutical, Shandong Luye (more declaration), Lizon Pharmaceutical, Shenyang Pharmaceutical (more declaration), Tianjin Takeda, Xi 'an Janssen, etc.