Pharmaceutical preparation process, so that the pill smaller curative effect becomes better

Bioavailability refers to the relative amount of a drug absorbed into the systemic blood circulation after being administered through the extravascular route, and represents the extent to which the active drug in the drug preparation is utilized throughout the body.

Researchers try to apply the emerging process technology of ultrafine pulverization to biopharmaceuticals, so that the powder formed after the substance is ultrafined has good surface properties, and the final drug is more dispersible and soluble. "After the improvement of the production process, the absorption of the drug is more rapid, and the dissolution rate is more than 10 percent higher than that of ordinary preparations." Liu Xiyi said.

"What is commendable is that the children's drugs we have developed are also widely praised in the market because of the improvement of preparation technology." Liu Xiyi said his drug, called Yilimei, is a dry suspension of acetaminophen, which is mainly used in children for fever caused by common cold or influenza. In terms of pharmaceutical ingredients, this is a classic drug, but the unique preparation technology makes the "old medicine with a new face."

"Although it is an old formula, we continue to study how to make it better in terms of taste acceptance and drug morphology." On the one hand, the taste is innovative, and the exclusive milk flavor is developed, so that children like this taste, and the medicine is really not bitter. On the other hand, in the form of innovation, we make this drug into a powder or granular substance, and when it is ready to shake with water, it can be dispersed into a suspension for oral administration. In addition to its effectiveness and chemical stability, it has a slow settling, and can be dispersed by gently shaking after settling. The size of suspended particles remains unchanged during long-term storage. Easy toppling and other physical characteristics." Liu Xiyi said.

The innovation and breakthrough in preparation has allowed the relevant technologies of Qingdao Guohai Biopharmaceutical to obtain invention patents, and has also made this drug the most effective and safest child fever reducer recommended by the World Health Organization.

In Zhu Renkuan's view, if China wants to realize the transformation of the raw material drug producing country to the pharmaceutical industry power, it must strengthen the research and development of pharmaceutical preparations, so as to improve the core competitiveness of China's pharmaceutical preparations industry in the international market, so that our people can enjoy cheap and high-quality good drugs.

There are many kinds of pharmaceutical preparations

Medicine preparation as a subject, more and more people pay attention to, because people can not do without it when they are sick. It is generally divided into liquid and solid preparations. Liquid preparations are divided into internal or external liquid preparations, injections and eye drops. Solid preparations are divided into capsules, tablets and coated tablets.

Internal or external liquid preparation refers to the solid or liquid drug dissolved or dispersed in water, alcohol, fat oil or glycerin under certain conditions, and sometimes additives are added to increase the solubility and dispersion of the drug, increase the stability of the product or improve its undesirable odor.

An injection, also known as an injection, is a dosage form designed for injection into the human body. The production method is usually to dissolve the API in water for injection (or oil for injection, or other appropriate solvent) to the required concentration, filter with a filter rod or microporous filter membrane, and fill the ampoule (or infusion bottle) through a pooper sealing machine.

Eye drops are external sterile liquid preparations directly applied to the eyes, mainly aqueous solutions.

Tablet refers to the grinding and screening powder and auxiliary materials (excipients, disintegrators, etc.) of the raw material are mixed evenly in the mixing machine, adding an appropriate amount of wetting agent and adhesive, making particles on the granulator, adding lubricants after drying, stamping and forming on the tablet press.

Coated tablets are sugar-coated tablets, enteric-coated tablets and thin-film coated tablets made by the coating machine after secondary processing.

There are two kinds of capsules: hard capsules and soft capsules. The hard capsule is made by mixing the raw powder and auxiliary material into a hard hollow capsule. Soft capsules are made by sealing oil or liquid drug or suspension that does not dissolve gelatin in a round or oval soft capsule to make a soft preparation for internal consumption.

Aerosol is the drug and the projectile are packed together in a pressure container with a valve, and can be used in a quantitative or non-quantitative spray in the form of a preparation.